Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Global emissions of greenhouse gases jumped 2.3 percent in 2013 to record levels, scientists reported Sunday, in the latest indication that the world remains far off track in its efforts to control global warming.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
"According to our survey last year, only 0.6 to 0.7 percent of students at universities were thinking about starting their own companies. The number among vocational school students was as high as 2.2 percent. However, the idea of vocational students starting businesses is related more to creating jobs for themselves, and the majority of them have chosen to have online shops."
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Martial art “China Youth”(Zhao Wenzhuo and friends)
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The World Health Organization this year declared H1N1 a global epidemic. Fortunately, it is much less threatening than people previously believed, and newly introduced vaccines seem to have quelled lingering fears.
Trends and targets in antiviral phototherapy
The pandas did some tai-chi in Trafalgar Square before kicking on at a panda party in Convent Garden as part of the first ever Panda Awareness Week.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
The second most sought-after job, according to Zhonggong, was a position offered by the regional earthquake bureau in the Inner Mongolia autonomous region, which had 768 applicants as of Tuesday.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
He also has serious thrill issues dude.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The scientists’ analysis comes only a month after nearly 200 governments struck a new climate agreement in Paris that aims to stop global temperatures from rising more than 2C from pre-industrial levels, and ideally limit warming to 1.5C.
位居榜单第三的是史蒂夫·卡瑞尔（Steve Carell）。《卑鄙的我2》（Despicable Me 2）在今年大获成功，斩获票房9.19亿美元。该电影系列累计已取得14亿美元的全球票房，该系列第三部《小黄人》（Minions）也即将上映。卡瑞尔今年还出演了小制作独立影片《迷途知返》（The Way Way Back）和《超级魔术师》（The Incredible Burt Wonderstone）。后一部影片的票房虽未能赚回制作成本，但是我们这里只关注票房收入——该部影片为卡瑞尔2013年的电影票房收入又添2,250万美元。
根据中国海关总署(General Administration of Customs)的数据，在经历了此前一个月的同比下跌1.4%之后，11月份中国的进口同比增长6.7%，至1522亿美元，远高于同比收缩1.9%的预测中值。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
I'm only a child yet I know we are all in this together and should act as one single world towards one single goal. 我身为小孩都知道，我们在地球的母亲怀中都是孩子。我们应该为了相同的目的进行相同的行动！
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
"Metro-Goldwyn-Mayer Inc. ('MGM') today announced that the secured lenders voting in the Company's solicitation process have overwhelmingly approved its proposed plan of reorganization ('Plan'). MGM will now move expeditiously to implement that Plan, which will dramatically reduce its debt load and put the Company in a strong position to execute its business strategy. MGM is appreciative of the lenders' support."
?The Aston Martin doesn't hurt. Not at all. Neither does dropping tons of cash at exotic casinos -- throwing money around makes men more attractive to women who are interested in flings. And, like Bond, men who gamble with women around are better at it.
Influenza neuraminidase: A druggable target for natural products
?Bond has a keen eye for who to trust and who not to. This quality is frequently seen in sexually open-minded people, actually. 007 can tell when a lady is into him. And science agrees: handsome men are the best at identifying who is attracted to them.
Hannah Kuchler is San Francisco correspondent
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
"The editors thought the articles were being sent out to genuine reviewers in the discipline," he said. "Following our investigation and communication with the real reviewers, they confirmed they did not conduct the peer review."
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
"Perhaps it is no big deal whether or not you are in the group discussion, but if you were absent, 670,000 people would be absent, if you were silent, 670,000 people would be silent."
The immediacy for a larger-screen iPhone comes partially from the Asian market where Samsung’s phablets have made significant inroads. Assuming that Apple’s agreement with China Mobile includes these upcoming products, the pricing adjustments that normally occur with new iPhones could make the iPhone 5C significantly more affordable and attractive to the Chinese market. This would begin to make sense of the 5C, which so far seems to be a sales disappointment for Apple. Perhaps the important thing about the 5C is that it is not the 5S, so that down the road it can be discounted without putting price pressure on Apple’s flagship.
Andrew Hill is management editor
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
8. How to dip dye hair
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
But the duo topped the trending celebrities section followed by 'X Factor' judges Gary Barlow and Tulisa.
Inhibition of SARS coronavirus helicase by bismuth complexes
Manufacturing has held up better, with profits growing 6.5 per cent, while profits from utilities such as electricity, heat and water grew 17 per cent, boosted by lower energy prices.
But John Davies, head of institutional investment in the Hong Kong team at CBRE, the property services business, says that lower prices should make the market more reliable. “The market is showing characteristics of a mature market, which institutional investors understand better,” he says.
Chinese manufacturers:Coming to the U.S.? Warren Buffett’s BYD says it is arriving in 2015 and Geely in 2016 but we’ve been hearing that someone was coming since at 2006. The refinement of Chinese cars is the issue. With more than 80 local automakers producing 524 different models in China, R&D money is spread too thinly to produce meaningful results.
“It’s fundamentally about ‘who are we?’” said Eric Kaufmann, a professor of politics at Birkbeck College, University of London. “What does it mean to be part of this nation? Is it not ‘our’ nation anymore, ‘our’ meaning the ethnic majority?
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Length of program: 24 months
Academics appear to be more interested in the cryptocurrency than ever before. There were 190 white papers published on bitcoin in 2014, up from 55 in 2013. Authors—amateur or otherwise—have also flocked to bitcoin: Amazon lists 437 books about or involving the term “bitcoin” published in 2014, compared to 143 in 2013. (That is based on a subject search, and thus includes less hard-hitting titles like Bitcoin Bimbo 3: Undercover Cop Science Fiction Erotica.) And sports fans this year may not have been able to ignore the inaugural Bitcoin St. Petersburg Bowl, a college football playoff game between North Carolina State and the University of Central Florida. ESPN quickly convertedBitPay’s $500,000 rights fee for the game into U.S. dollars.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The letter surfaced in a Pennsylvanian university mailroom earlier this month.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The expansion would be considered impressive in most markets, but it represents an ongoing slowdown for China, the world's second-largest film territory and a continual source of growth for Hollywood for the better part of a decade.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Lady Gaga以5.9千万位列第四，其后是5.45千万的碧昂斯。前者在统计期间演出了66场，也靠与范思哲和MAC的合约获得收入，同时还有她自己的黑色香水。后者与其老公Jay Z的On The Run巡回演唱会通过19天（北美日期），赚得了超过10千万，创造了能与滚石相比较的第一对音乐界夫妻档夜平均的神话。
You might think Hawaiian has it relatively easy, since its flights rarely have to contend with the kind of challenging weather conditions found on the mainland. Hawaiian perennially rates high in on-time performance rankings, topping the most recent DOT list i n September. It recently announced it will branch well beyond its island home with non-stop service to Beijing.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
For many Western whites, opportunities for achieved identity — the top of the hill — seem unattainable. So their ascribed identity — their whiteness — feels more important than ever.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
12. 最有希望的迹象。有段时间，你会觉得现状已经改善了，人们可以公开大声谈及业内的歧视现象。维奥拉·戴维斯(Viola Davis)出来说话，詹妮弗·劳伦斯(Jennifer Lawrence)公开谈起，自己比片中的合作男星片酬少。“我不想被视为‘难搞’或者‘被宠坏了’，”她在简报《伦尼》(Lenny)中为许多人发言，其中包括许多薪酬更低的人们。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Unlike most boy-band dudes going solo, he never sounds like he's sweating to get taken seriously – he never loses touch with the exuberance and swagger he brought to One Direction in the first place. So get used to this man – you'll be hearing a lot more from him.
"We hope the mother will come to us and verify the facts. If it's true that the user is a 13-year-old who spent the money without consent, we can negotiate a refund," the Tencent employee said.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Other top ten foreign pictures were Transformers: The Last Knight, Dangal, Pirates of the Caribbean: Dead Men Tell No Tales, and Kong: Skull Island.
Yes Man is a heartwarming blockbuster that explores what would happen if you answered "yes" to every question in your life. Jim Carrey's character takes on this challenge and ends up learning Korean, taking flying lessons, and getting promoted. He goes from being a pessimistic divorced man to an exciting trendsetter and finds a new girlfriend in the process. It might sound like fiction, but this movie is loosely based on a memoir of the same name by freelance radio producer Danny Wallace.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
6.The Conjuring 2：The Enfield Poltergeist
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Last year was especially striking because global heat records were broken or tied in every month except January and April, researchers said.
John Hummel, chief investment officer for AIS Group, a fund manager with $400 million under management, said all the new sources of global oil are expensive to extract, and he sees U.S. shale output falling by 2015.
1) I make contact easily when I meet people 0 1 2 3 4
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Transport Ministry spokesman Xu Chengguang told a news conference that no further signs of life had been found and the chance of finding anyone else alive was "very slim."
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
After weeks of nail-biting auditions and five days of tense semi-finals, Britain’s Got Talent picked one of the 11 acts to be the 2014 champion.
Trailing China in 2015 was the UK with $1.9 billion, Japan, $1.8 billion, India, $1.6 billion, and South Korea, $1.5 billion.
A modular microarray imaging system for highly specific COVID-19 antibody testing
今年由美国电影学会的电影评审总监是Tom Pollock，担任电视剧评审总监的是Richard Frank。评审团的其他成员还包括Judd Apatow, Halle Berry, Jamie Lee Curtis, Leonard Maltin,来自知名大学的著作家，学者，公认的电影艺术家，还有像媒体NPR,Rolling Stone, TV Guide, 华盛顿邮报对于电视电影的评论家们。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
The report also found that the top cities in intellectual capital and innovation and technological readiness also achieved high scores in the overall ranking, a clear indication that technologically advanced cities were more likely to earn the title of "cities of opportunity".
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
两周后，伯恩海默等几十位著名的早期绘画大师作品交易商出席伦敦的夜间拍卖会。过去，他们通常会在这些拍卖会上购买一些作品，以备在第二年3月的荷兰马斯特里赫特欧洲美术博览会(Maastricht European Fine Art Fair)上展示。但是由于卖家们鼓励苏富比和佳士得报出更高的估价来争夺自己的拍品，所以拍卖行只针对少数富豪进行宣传，现场竞价十分冷清。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The Magic are the single-most mystifying team in this entire exercise. They make little sense on paper or on the court.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
A combination of tax increases and spending cuts in 2013 shaved about 1.5 percentage points off annual economic growth, according to the Congressional Budget Office. Many forecasters expect the fiscal drag in 2014 to be one-third that amount, or less. 'You'll have more political certainty this year,' said Gregory Daco, a U.S. economist at Oxford Economics.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
*最佳真人秀主持：鲁保罗?查尔斯(RuPaul Charles)，《鲁保罗变装皇后秀》(RuPaul’s Drag Race, Logo)
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Yes, 2014 is an absolute total disaster just waiting to ignite. In 'Doomsday poll: 87% risk of stock crash by year-end' we analyzed 10 major crash warnings since early this year. Since then, more incoming bogies raced across our radar screen. Ticking time bombs from Congress, the Supreme Court, sex, carbon emissions, Big Oil, NSA, IRS, Tea Party austerity. Relentless. Mind-numbing.
After the success of The Conjuring, Ed Warren and Lorraine Warren are back to kick some ghost butts. Conjuring 2 is based on the Enfield Poltergeist, which is apparently a true event that took place in London in 1977.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Wheel skates look somewhat like regular inline skates, except that the wheels are much larger, up to the size of bicycle tires. They are seen as a cross between an inline skate, a ski, and a bike. Recently, a company called Chariot Skates said they had come up with something unique—the Chariot wheel skates. According to the company, wheel skates are "revolutionary new skating products." Revolutionary? They do at least revolve. New? No. The first wheel skate was made more than 142 years ago.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
London Business School has topped the European table for the third year running — but continental rivals lead the European schools in the individual rankings used to compile it.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
"I'm always amazed at how many people tell their co-workers about their job search," Kay says. "That's one of the worst things you can do." Ideally, you wouldn't tell any co-workers, but you may have to if you want them to serve as references. In that case, Kay says, "you need to pick people who you really trust, who don't have a hidden agenda and who won't let it slip."
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
On Her Majesty's Secret Service gets an honorable mention on our list of James Bond Theme songs.
In this Sept. 18, 1990, file photo, Steve Jobs, president and CEO of NeXT Computer Inc., shows off his company's new NeXTstation after an introduction to the public in San Francisco
Length-scale dependence of protein hydration-shell density
Moonlight, an evocative coming of age story about a young gay black man, won best picture at the 2017 Oscars but was almost denied its victory in chaotic scenes when the award was mistakenly given to La La Land.
May the beauty and joy of New Year remain with you throughout the new year!愿新春美景与欢乐常伴随你！
This year's lift was slower than the 6.5% rise in 2016, which is attributed to moderating economic growth and a rapidly aging society.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Among the top 50 richest women in the world, entrepreneurs from the Chinese mainland account for 56%.
剧情类最佳剧集：《权力的游戏》(Game of Thrones, HBO)
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Six regions recorded GDP growth less than 7 percent, with China's north-eastern rust belt Liaoning province at the bottom with negative growth.
"A total of 297 projects will be carried out in Tongzhou, such as building new subway lines and expressways, and improving ecologies," Lu Yan, director of the Beijing Municipal Commission of Development and Reform, said at a news conference on Wednesday.
About this collection
The seven large brick tombs were likelyconstructed for people of wealth, the researchers said.